D. Chiarino, F. Ferrario, F. Pellacini
May 1, 1989
Citations
0
Influential Citations
26
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
A number of 2-substituted-4-thiazolidinecarboxylic acid derivatives were synthesized by cyclocondensation of L-cysteine or its esters with various aldehydes, resulting from acids provided with antiinflammatory properties. In the cyclocondensation a new chiral center at C-2 position of thiazolidine ring is formed giving rise to a mixture of diastereoisomers which can be partially separated. These diastereoisomers show in solution a fast epimerisation at the same chiral center as evidenced by 1H-nmr studies.