S. Somaiah, S. Sashikanth, V. Raju
Jan 17, 2011
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Tetrahedron-asymmetry
Abstract
Abstract An asymmetric conjugate addition reaction between a chiral α,β-unsaturated amido ester and ethyl- N -methylmalonamide has been used as a key step in the synthesis of (3 S ,4 R )-(−)- trans -4-(4′-fluorophenyl)-3-hydroxymethyl- N -methylpiperidine, a key intermediate for (−)-paroxetine.