A. Aly, A. El-Gazzar, H. Hussein
Jan 1, 2007
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Phosphorus, Sulfur, and Silicon and the Related Elements
Abstract
Polynuclear thieno[2,3-d]pyrimidone derivatives had been synthesized by an intermolecular reaction of 2-hydrazino-thieno[2,3-d]pyrimidin-4-one (1) with each of the aliphatic acids, and carbon disulfide afforded thienotriazolepyrimidin-5-one derivatives. On the other hand, compound 1 that condensed with α-haloketone yielded thienopyrimidotriazine, and with β-diketones and β-ketoesters formed 2-(1-pyrazolyl) derivatives. Also, the condensation of compound 1 with aromatic aldehydes gave arylhydrazones. The purpose of synthesis the thienopyrimidine derivatives is due to high biological activities. 4-chloro derivatives exhibited spasmodic and antiviral activity, and also 4-amino derivatives showed antimicrobial, insecticidal, pesticidal, and acaricidal activity.