S. Bhinge, Vanita Chature, L. Sonawane
Sep 1, 2015
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Journal
Pharmaceutical Chemistry Journal
Abstract
The present manuscript describes synthesis of some new 1,3,4-thiadiazole derivatives and evaluation of their antimicrobial, antifungal and anthelmintic activity quantitatively and qualitatively. First, thiosemicarbazide was cyclized with different aromatic acids and ethanol to yield 5-phenyl-1,3,4-thiadiazol-2-amine. Then, N-substituted alpha-chloroacetanilides were synthesized from aromatic amines and chloroacetyl chloride in a mixture of glacial acetic acid and sodium acetate under cold conditions. Finally, 5-phenyl-1,3,4- thiadiazol-2-amine was reacted with N-substituted alpha-chloroacetanilides using potassium hydroxide to yield the corresponding N-phenyl-2-[(5-phenyl-1,3,4-thiadiazol-2-yl)amino] acetamides. The structures of synthesized compounds were confirmed by IR and 1H NMR spectra and elemental analysis. These molecules were evaluated for antimicrobial, antifungal and anthelmintic activity.