N. Kumar, U. Mashelkar
May 1, 2008
Citations
0
Influential Citations
2
Citations
Journal
ChemInform
Abstract
Substituted 2H-pyrano[3, 2-e][1,2,4]triazolo[4,3-a]pyridine 3a-f and 4a-b have been prepared starting from 5-methyl-6-cyano-7-hydrazino-2-oxo-2H-pyrano[2,3-b] pyridine-3-carboxylic acid 2. The compound 2 is prepared by reacting ethyl-5-methyl-6-cyano-7-chloro-2-oxo-2H-pyrano [2,3-b]pyridine-3-carboxylate 1 with hydrazine hydrate at room temperature with good yield. Condensation of 2 with acids results in the formation of 1-substituted 2-pyrano[3,2-e][1,2,4]triazolo[4,3-a]pyridine (3a-f), further the hydrazine derivative 2 has been transformed to 1 -aryl-2H-pyrano[3,2-e][l,2,4]triazolo[4,3-a]pyridine (4a-b). These compounds are expected to have antihypertensive activity.