V. Dabholkar, T. Ravi
May 1, 2010
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0
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Journal
ChemInform
Abstract
The compound 4-[(2,4-substituted benzylidine)-amino]-3thioxo-1,2,4-triazin-5-one 2 is treated with bromine in glacial acetic acid to yield, 4-[(2,4-substituted benzylidine)-amino]-6,6dibromo-3-thioxo-1,2,4-triazin-5-one 3. The dibromo compound 3 is then subjected to reaction with substituted triazoles and amino thiophenol to furnish, 1-thia-2,3-(3′-substituted)-triazolo-4,6,7,9tetraza-4,6,7-trihydro-8-thioxo-10-oxo-9[(2"/4" substituted benzylidine)-amino]spiro[4.5]decane 4 and, 1-thia-2,3-(3'substituted)-benzo-4,6,7,9-tetraza-4,6,7-trihydro-8-thioxo-10-oxo9[(2"/4" substituted benzylidine)-amino]spiro[4.5]decane 5, respectively. The compounds have been synthesized by conventional methods. The IR, H NMR, C NMR and mass spectral fragmentation patterns of some prepared compounds have been investigated to elucidate the structure of the synthesized compounds. The final compounds have also been screened for microbiological activity, which show some inhibitory action against gram positive and gram negative micro organisms.