B. Tozkoparan, G. Aktay, E. Yeşilada
Jun 1, 2001
Citations
0
Influential Citations
12
Citations
Quality indicators
Journal
Arzneimittelforschung
Abstract
Summary In this study, 21 new compounds having 2-methyl-6-benzylidenethiazolo [3,2-b] -1,2,4-triazol-5(6H)-one (2–4) and 2-methyl-6- (α-aminobenzyl) thiazolo [3,2-b]-1,2,4-triazole-5-ol (2a-4g) structures were synthesized. The structures of the compounds were proved by spectral and elemental analysis. All of the compounds synthesized were tested for their anti-inflammatory activiy and ulcerogenic potential in mice at 10, 20 and 40 mg/kg dose levels. Compound 4b showed higher anti-inflammatory activity than the analogue derivatives and Indometacin (CAS 53-86-1), used as a reference drug, at 10 mg/kg dose level. Generally, the compounds were found to be more reliable than Indometacin since they did not cause any reaction in the stomach.