A. B. A. El‐Gazzar, A. M. Gaafar, A. Aly
Jan 1, 2002
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Influential Citations
14
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Journal
Phosphorus, Sulfur, and Silicon and the Related Elements
Abstract
6-Amino-2,3-dihydro-2-thioxo-4(1 H )-pyrimidinone 1 reacts in boiling DMF with a cyclic f , g -unsaturated ketones 2 affording the pyrido [2,3- d ]pyrimidinone 6a , b , the latter compound condensed with aldehyde in presence of chloroacetic acid to yield thiazolo[3,2-a] pyrido [2,3-d]-pyrimidinones ( 7 , 8 ) respectively. The alkylation of pyridopyrimidinone it gave the 2-alkylthio derivatives 10a-e , compound 10b cyclized to thiazolopyridopyrimidinone derivative 13 . Also, the condensation of compounds 7a , b with hydoxylamine gave the corresponding isoxazolo[5',4':4,5]thiazolo[3,2-a]pyrido[2,3-d]pyrimidinone.