J. A. Gomez, James R. Green, K. Vollhardt
Apr 1, 2011
Citations
0
Influential Citations
2
Citations
Journal
Synlett
Abstract
The CpCo(CO)2-catalyzed cocyclization of 1,2-diethy- nyl-4-methoxybenzene with alkynes can be applied to the synthesis of 'spacer'-naproxen (2-(6-methoxybiphenylen-2-yl)propanoic ac- id) and its 7-methoxy isomer, 'spacer'-isonaproxen. While unsym- metrical alkynes are incorporated without regioselectivity, the methoxy group in 6-methoxy-2,3-bis(trimethylsilyl)biphenylene directs electrophiles to C-3, thus allowing for regiochemical differ- entiation between the 2- and 3-positions.