Qi Jian
2001
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Journal
Chinese Journal of Pharmaceuticals
Abstract
Sparfloxacin was synthesized from 2,3,4,5 tetrafluorobenzoic acid via nitronation, acyl chlorination, condensation with diethyl malonate, partial hydrolysis and decarboxylation, condensation with triethyl orthoformate, cyclopropylamine displacement, cyclization, reduction, hydrolysis, and then condensation with 2,6 dimethylpiperazine. The overall yield was about 28%.