L. Tomachynski, V. Chernii, Helena N. Gorbenko
Jun 1, 2004
Citations
1
Influential Citations
18
Citations
Quality indicators
Journal
Chemistry & Biodiversity
Abstract
The new axially substituted phthalocyanine (pc) complex of zirconium(IV) with citric acid is reported. It has been shown that the replacement of two Cl‐atoms with two citric acid fragments takes place as the result of the reaction between [ZrCl2(pc)] and citric acid. The complex [Zr(citrate)2(pc)] was formed. The spectroscopic properties of the synthesized compound in DMSO, RPMI 1640 medium with and without fetal calf serum (FCS), H2O, and buffer (Tris) solutions have been described. Antitumor activity of this compound has been studied. The cytostatic activity was observed in the concentration range of 6.1–9.0×109 molecules [Zr(citrate)2(pc)]/cell and occurred in 4–6 h after treatment with [Zr(citrate)2(pc)] solution.