S. Al-Nuzal, Muhammad F. Al-Dulaimi, A. T. Hassan
Feb 9, 2022
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Journal
Journal of University of Anbar for Pure Science
Abstract
Most of the derivatives showed variable chemical reactivities and thermal stability, and the N1 and N3 disubstituted analogue were found much less stable, and hydrolyzes easily in the reaction medium. According to 1 H and 13 C NMR measurement's, 1,3-Dichloro-5,5-diphenyl imidazolidine-2,4-dione (V) was found to chlorinate the methyl group of the solvent DMSO-d6. Sodium hydroxide consumption analysis was established to reveal the molecularity against NaOH, by following acidbase volumetric method. key words: Phenytoin; 5,5-diphenyl 2,4-imidazolidinedione (I); sodium hydroxide consumption analysis; antiepileptic drug; acylation; halogenation; reduction; and nucleophilic substitutions.