M. El-Gaby, J. Micky, N. Saleh
Jun 1, 2015
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Journal
Chinese Chemical Letters
Abstract
Abstract 2-Aminocyclopenta[ d ]pyrimidines 3a–c were achieved via a one-pot, three-component reactions of cyclopentanone 1 , aromatic aldehyde and guanidine hydrochloride (1:2:1 molar ratio). Also, cyclization of 2,5-bis-(arylmethylidene)cyclopentanones 2 with guanidine hydrochloride (1:1 molar ratio) in methanol in the presence of sodium methoxide afforded cyclopenta-[ d ]pyrimidines 3 . Compound 3c has been shown to be a useful building block for the synthesis of some novel pyrimido[1,2- a ]pyrimidines 5 , 7 and 12 . The structures of the newly synthesized compounds were confirmed on the basis of analytical and spectral data.