A. Vereshchagin, M. Elinson, Y. Anisina
Oct 15, 2017
Citations
0
Influential Citations
26
Citations
Journal
Journal of Molecular Structure
Abstract
Abstract Multicomponent synthesis of 5-C substituted 2,4-diamino-5H-chromeno[2,3-b]pyridine-3-carbonitriles from salicylaldehydes 2-aminoprop-1-ene-1,1,3-tricarbonitrile and 1,3-cyclohexanediones was carried out in 59–88% yields. The structures of compounds obtained were characterized by several techniques, including elemental analysis, IR, XRD, mass, 1H, 13C and NOESY spectral studies. The chromeno[2,3-b]pyridines obtained are enols in solid phase. Keto-enol equilibrium is observed in DMSO solutions. Molecular docking studies of the synthesized chromeno[2,3-b]pyridine-3-carbonitriles were also carried out to elucidate their relationship with the binding pockets of the mitogen activated protein kinase (MK). It have been found that chlorine-containing chromeno[2,3-b]pyridines have best binding energy both MK-1 and MK-2.