Pundlik Shinde, S. Srivastava, R. Odedara
Feb 1, 2009
Citations
0
Influential Citations
29
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
Various spiro[chroman-2,4'-piperidin]-4-one derivatives (38a-m and 43a-j) have been designed, synthesized and evaluated for in vitro acetyl-CoA carboxylase (ACC) inhibitory activity. Several compounds have shown ACC inhibitory activity in low nanomolar range. Compound 38j reduced the respiratory quotient (RQ) in C57BL/6J mice indicating increase in whole body fat oxidation even in the presence of high carbohydrate diet. Structure-activity relationship (SAR) has been discussed.