Dong‐Zhen Chen, W. Xiao, Jia‐Rong Chen
Jun 27, 2017
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Influential Citations
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Journal
Organic chemistry frontiers
Abstract
A formal [4 + 1] annulation reaction of 3-bromooxindoles and in situ-derived 1,2-diaza-1,3-dienes in the presence of Cs2CO3 as the base has been developed for the first time. This protocol provides an efficient and mild approach for the synthesis of various biologically interesting spiropyrazoline oxindoles in generally high yields. A one-pot, three-component variant also worked smoothly to give the desired products in comparable yields.