Gen-ichi Tsuchihashi, Shuichi Mitamura, Katsuyuki Ogura
1979
Citations
0
Influential Citations
15
Citations
Journal
Bulletin of the Chemical Society of Japan
Abstract
(S,S)-2-Amino-3-phenylbutyric acid was synthesized starting from diethyl (R)-(1-phenylethyl)malonate which was obtained by desulfurization of the adduct in the stereoselective Michael reaction of (R)-styryl p-tolyl sulfoxide with diethyl malonate. This synthetic amino acid was identical with the 2-amino-3-phenylbutyric acid obtained by degradation of bottromycin and thus the absolute configuration of the naturally occurring amino acid was proved to be (S,S).