O. Attanasi, P. Filippone, B. Guidi
2001
Citations
0
Influential Citations
8
Citations
Journal
Synthesis
Abstract
Synthesis 2001, No. 12, 25 09 2001. Article Identifier: 1437-210X,E;2001,0,12,1837,1845,ftx,en;E03501ss.pdf. © Georg Thieme Verlag Stuttgart · New York ISSN 0039-7881 Abstract: 1,2-Diaza-1,3-butadienes react regioselectively with trifluoromethylated b-dicarbonyl compounds to give stable 2-(trifluoromethyl)-2,3-dihydro-1H-pyrrol-2-ol derivatives, which upon treatment with trifluoromethanesulphonic anhydride or with heterogeneous catalysts give rise to fluorinated 1-aminopyrrole derivatives in good to excellent yields. The reaction of 2(trifluoromethyl)-2,3-dihydro-1H-pyrrol-2-ol derivative with 2-haloketone affords fluorinated furo[2,3-b]pyrroline derivative, while that of diethyl 1-[(anilinocarbonyl)amino]-2-methyl-5-(trifluoromethyl)-1H-pyrrole-3,4-dicarboxylate with hydrazine hydrate affords fluorinated pyrrolo[3,4-d]pyridazindione derivative.