D. Holt, H. Oh, M. Levy
Jan 31, 1991
Citations
0
Influential Citations
10
Citations
Journal
Steroids
Abstract
Abstract The synthesis of 17β-(N, N-diisopropylcarbamoyl)estra-1,3,5(10)-triene-3-sulfonic acid (3) has been accomplished. Sulfonate 3 was designed as a novel inhibitor of human steroid 5 α-reductase based on considerations of enzyme mechanisms, and exhibits an inhibition constant in the low nanomolar range.