Yuan Zhe-dong
2007
Citations
0
Influential Citations
0
Citations
Journal
Chinese Journal of Pharmaceuticals
Abstract
Strontium ranelate, a bone formulation stimulant, was synthesized from diethyl 1,3-acetonedicar- boxylate by cyclization with sulfur and malononitrile, condensation with ethyl chloroacetate to give 5-[N,N- bis(ethoxycarbonylmethyl)amino]-4-cyano-3-ethoxycarbonylmethyl thiophene-2-carboxylic acid ethyl ester, which was subjected to alkaline hydrolysis with strontium hydroxide in 34% overall yield.