Aziz‐ur‐Rehman, Samreen Gul, M. Abbasi
Jul 3, 2015
Citations
0
Influential Citations
6
Citations
Quality indicators
Journal
Phosphorus, Sulfur, and Silicon and the Related Elements
Abstract
GRAPHICAL ABSTRACT Abstract A series of new 5-substituted aryl/aralkyl-1,3,4-oxadiazol-2-yl 4-(morpholin-4-ylsulfonyl)benzyl sulfides 6a–k were synthesized by converting multifarious aryl/aralkyl organic acids 1a–k successively into corresponding esters 2a–k, hydrazides 3a–k, and 5-substituted aryl/aralkyl-1,3,4-oxadiazole-2-thiols 4a-k. Finally, the target compounds, 6a–k were prepared by stirring 5-substituted-1,3,4-oxadiazole-2-thiols with 4-(4-(bromomethyl)phenylsulfonyl) morpholine (5) in the presence of N,N-dimethylformamide (DMF) and sodium hydride (NaH). The structures of the newly synthesized compounds were elucidated by spectroscopic techniques. In addition, the antibacterial activity of all the synthesized compounds was investigated in vitro against Gram-positive and Gram-negative bacteria by using ciprofloxacin as reference standard drug and the results showed that some of the tested compounds possessed good antibacterial activity.