Cheng De-ju
2015
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Journal
Journal of Inner Mongolia Normal University
Abstract
Interest in the methylbenzenesulfonamide has been increasing due to pyridine,benzenesulfonyl,bromine atom such as active group.The small molecular antagonists can be used as a targeting preparation in the prevention of human HIV-1infection.4-methyl-N-ethyl-N-(piperidin-4-yl)benzenesulfonamide(intermediate 7)was prepared from N-Benzyl-4-piperidone.4-bromo-1-((4-chlorobenzyl)oxy)-2-(bromomethyl)benzene(intermediate 3)was synthesized from 1-chloro-4-(chloromethyl)benzene.Further reaction of 7with 3gave a novel compound 4-methyl-N-(1-(5-bromo-2-((4-chlorobenzyl)oxy)benzyl)piperidin-4-yl)-N-ethylbenzenesulfonamide.The compounds were characterized by 1 H NMR,MS,IR and bioactivity.The compound can be used as the candidate compounds for drug development.