M. Abbasi, A. Akhtar, Aziz‐ur‐Rehman
Dec 1, 2013
Citations
1
Influential Citations
10
Citations
Journal
Journal of The Chilean Chemical Society
Abstract
In the present work, S-substituted derivatives of 5-(2-nitrostyryl)-1,3,4-oxadiazole-2-thiol (4) were synthesized by successive conversions of 3-(2-nitrophenyl) acrylic acid (1) into its respective ester, hydrazide and 1,3,4-oxadiazole. Finally the target compounds were obtained by reaction of 5-(2-nitrostyryl)-1,3,4oxadiazole-2-thiol (4) with a series of various electrophiles, (5a-I), in N,N-dimethyl formamide (DMF) in the presence of sodium hydride (NaH). The structural characterization of these newly synthesized compounds was done by IR, 1H-NMR, HR-MS and EI-MS spectral data. All these compounds were evaluated for their