Tomasz Han, Rafał Petrus, Dominik Bykowski
Oct 13, 2015
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Influential Citations
13
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Organometallics
Abstract
Five novel magnesium alkoxides supported by drug chelating agents pridinolum (PriOH = 1,1-diphenyl-3-(1-piperidinyl)-1-propanol) and venlafaxinum (VenlOH = (RS)-1-[2-dimethylamino-1-(4-methoxyphenyl)-ethyl]cyclohexanol) were successfully synthesized and characterized. Direct reaction of PriOH and VenlOH with MgBu2 (1:1) in toluene gives the dimeric compounds [Mg(μ,η2-OPri)nBu]2 (1) and [Mg(μ,η2-VenlO)nBu]2 (2), respectively. Furthermore, the crystallization of an equimolar mixture of 1 and 2 in toluene yields heteroleptic magnesium complex [Mg(μ,η2-OVenl)(η1-OPri)]2 (3). Moreover, reactions of 1 and 2 with 2 molar equivs of the corresponding drug–ligands give the homoleptic magnesium bis-alkoxides [Mg(μ,η2-OPri)(η1-OPri)]2 (4) and [Mg(μ,η2-OVenl)(η1-OVenl)]2 (5). The treatment of compound 1 with 2 equivs of VenlOH or 2 with 2 equivs of PriOH leads to the formation of 3. Complexes 1–5 were characterized by elemental analysis, nuclear magnetic resonance, and single crystal X-ray diffraction (for 1–4). It wa...