Bian Hong
2005
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Journal
Chinese Journal of Pharmaceuticals
Abstract
The trans-isomer(2)of milnacipran hydrochloride(1)was synthesized from(±)-(1S,2S)-2-hydroxymethyl-1-phenylcyclopropanecarboxylic acid via bromination, acyl chloridation, amidation, Gabriel reaction and HClsalt formation in 19% overall yield. The 1HNMR and NOSEY data were compared between 1 and 2. The trans-isomer may beserved as the reference in the quality control of 1.