B. MahyavanshiJyotindra, A. ParmarKokila, K. MahatoAnil
Oct 1, 2011
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Indian journal of applied research
Abstract
A new series of 2-[4-phenyl-5-(pyridine-4-phenyl)-4H-[1,2,4]triazole-3ylSulfanyl]-N-aryl-acetamide have been synthesized by the condensation of 4-phenyl-5-(pyridine-4-yl)-4H-1,2,4-triazole-3-thiol and 2-Chloro-N-(aryl)acetamide in presence of anhydrous potassium Carbonate. The Structure of Synthesized compound was assigned by H1NMR,MASS Spectra,IR Spectra and Elemental Analysis . All the compound were Screened for their in-vitro Antibacterial, Antifungal and anti tuberculosis activity. Introduction The synthesis of compound containing 1,2,4 triazole ring system has attracted attention because of its wide range of pharmaceutical activity. A variety of biological compound such as anti-inflammatory, analgesic, antibacterial, antifungal, anti tubercular, antiviral, antitumor, anticonvulsant, and anti depressant have been reported for Mercapto and thione substituted 1,2,4 triazole ring system1,2,7. In last few decades the chemistry of 1,2,4triazole and their fused heterocyclic derivatives has received important because of there effective biological importance. A wide number of drugs containing 1,2,4-triazole ring system are incorporated because of there wide therapeutically interests including anti inflammatory, CNS stimulants, sedatives, anti anxiety, such as fluconazole, intraconazole, Voriconazole, Also there known drug containing the 1,2,4-triazole group eg. Triazolam, Alprazolam, Etizolam and Furacylin2,6,8. Moreover sulphur containing heterocycles represents important group of sulphur compound that are promising for use in practical application3. Among these heterocycles the Mercapto and Thione substituted 1,2,4-triazole ring system have been well studied4,9. Acetanilide derivatives are reported to exhibit a number of biological activities including anesthetic, antipyretic, anti inflammatory, and anti bacterial effects substitution including alkyl thio and alkenylthio derivatives have been carried out primarily at the third position of the 1,2,4-triazole ring as potential antimicrobial agents5,1. In continuation of our interest on chemistry of functionalized chloroacetamide derivatives because of the high mobility of chloride atom and reactive N-H group compound containing chlorocetamide. Materials and Methods All melting points were determined using open capillary tubes on electronic apparatus and were uncorrected. The IR spectra (4000-400 cm-1) of synthesized compounds were recorded on Shimadzu 8400-s FTIR spectrometer with KBr pellets. To monitor the reactions, establish the identity, purity of reactants and products, thin layer chromatography performed on TLC coated with silica gel using appropriate mobile phase system and spots visualized under UV radiation. Nuclear magnetic resonance spectra was recorded using Bruker 400 MHz model spectrometer using DMSO as a solvent and TMS as internal standard (Chemical shifts in d ppm). All new compounds subjected to elemental analysis and the results obtained were in acceptable range. N O