T. Hua
2013
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0
Influential Citations
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Citations
Journal
Chinese Journal of Pharmaceuticals
Abstract
In the quality study of cefminox sodium sterile,a new impurity was identified by HPLC-MS.Its structure was speculated to be sodium(6R,7S)-7-[[[[(2S)-2-amino-2-carboxyethyl]thio]acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-7-methylthio-8-oxo-5-thia-1-azabicyclooct-2-ene-2-carboxylate,and it was synthesized via substitution,acylation,deprotection and substitution from benzhydryl(6R,7S)-7-amino-7-methoxy-3-[(1-methyl-1H-tetrazol-5-ylthio)methyl]-8-oxo-5-thia-1-azabicyclooct-2-ene-2-carboxylate and methanthiol.The structure was confirmed by 1H NMR and MS.It had the same peak retention time as the new impurity of cefminox sodium.