Xing-hai Liu, Li Pan, Jianquan Weng
Jan 17, 2012
Citations
0
Influential Citations
45
Citations
Quality indicators
Journal
Molecular Diversity
Abstract
To develop novel inhibitors of ketol-acid reductoisomerase, a series of (oxdi/tri)azoles derivatives was synthesized and characterized by 1H NMR, MS, elemental analyses, and crystallography. According to the biological activities of these compounds obtained both in vivo and in vitro, compound 4-cyclopropyl-3-((4-fluorobenzyl)thio)-5-methyl-4H-1,2,4-triazole showed excellent KARI inhibitory activity (100% at 100 μg mL −1 in vitro). In addition, most of the title compounds exhibited good herbicidal activity against Brassica campestris in vivo.