Q. Miao, Xiaowei Yan, Kejian Zhao
May 11, 2010
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Journal
ChemInform
Abstract
An anticancer active compound 1-[(5-bromo-2-thienyl)sulfonyl]-5-fluoro-1,2,3,4-tetrahydropyrimidine-2,4-dione (1) was synthesized by the modified Schotten-Baumann reaction of 5-fluorouracil with 5-bromo-2-thienyl-sulfonyl chloride and characterized by elemental analysis, IR, 1H and 13C NMR spectra. The single crystal X-ray diffraction analysis shows that the title molecule forms a two dimensional sheet structure by three kinds of hydrogen bond interactions. Its thermal stability was studied by TGA technique. Based on inhibition ratio against cancer cell growth, compound 1 has obvious anticarcinogenic activity against HL-60 and BEL-7402 cancer cells.