Palanichamy Santhosh Kumar, D. Premnath, A. Obadiah
Dec 1, 2019
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Quality indicators
Journal
Current Pharmacology Reports
Abstract
A series of 3-amino-5-(5-oxo-5H-benzo[a]phenothiazin-6-ylamino) benzoic acid derivatives were synthesized by the Michael addition of 2,3-dichloronaphthalene-1,4-dione and 3,5-diaminobenzoic acid. All the synthesized compounds are screened for their bioactivity through molecular docking, cytotoxicity (against HeLa), and antioxidant activity. DPPH and ABTS evaluation procedures are employed to assess the antioxidant activity. Among the synthesized derivatives (1, 2, 3a–g), the compound 3d exhibited the highest inhibition of 77% and 80% in the DPPH and ABTS antioxidant activity evaluation, respectively. The compound 3d exhibited better glide and E model scores when docked with HDAC8 using the GLIDE program. Cytotoxicity of the synthesized compounds was studied against cervical cancer cell line (HeLa), and compound 3d showed the maximum inhibition and displayed a better activity than the standard drug.