Fatima Doganc
Mar 13, 2023
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Ankara Universitesi Eczacilik Fakultesi Dergisi
Abstract
Objective: In this study, in connection with previous works in our department, some methyl 1H-benzimidazole-5-carboxylate derivatives were synthesized for the first time. Compounds were modified by substituting the second position of the benzimidazole ring with 4-methylpiperidinyl groups for increasing antibacterial activity. Material and Method: The targeted methyl 1H-benzimidazole-5-carboxylates were synthesized by the reaction of o-phenylendiamine derivatives with urea. Oxygen at the 2nd position was converted to the chlorine in the presence of POCl3. Finally, the resulting products were obtained by the nucleophylic reaction with 4-methylpiperidine. Structures of synthesized compounds were elucidated with 1H- 13C-NMR and LC-MS techniques. Result and Discussion: Methyl 1H-benzimidazole-5-carboxylate derivatives that bearing 4-methyl piperidinyl groups at 2nd position were synthesized for getting better in vitro antibacterial activity profiles. In vitro antibacterial activity of the synthesized compounds in this study are under investigation.