Guo Qian-yi
2011
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Journal
Journal of Guangdong Pharmaceutical University
Abstract
Objective To design and synthesize 7-chloro-4-{4-[2-(2-methyl-imidazol-1-yl) ethyl]-piperidine-1-yl} qinoline,a potential anti-malarial agent.Methods The target compounds were obtained via amino protection,nucleophilic reaction and deprotection,which were purified by silica gel chromatography.Results The products′ structures were characterized by IR,GC-MS and 1H-NMR.Conclusion The synthesis method is feasible with high yields,and can be used for the synthesis of derivatives containing a 4-piperazinyl quinoline ring.