N. H. Powell, G. Clarkson, R. Notman
Jul 10, 2014
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0
Influential Citations
37
Citations
Journal
Chemical communications
Abstract
A new class of peptidomimetic is reported in which one of the amide C=O bonds of the peptide backbone is replaced by an oxetane ring. They are synthesised by conjugate addition of various α-amino esters to a 3-(nitromethylene)oxetane, reduction of the nitro group and further coupling with N-Z protected amino acids to grow the peptide chain. Structural insights are provided by X-ray diffraction and molecular dynamics simulations.