Y. Tezuka, M. Kudoh, Y. Hatanaka
Feb 1, 1997
Citations
0
Influential Citations
3
Citations
Journal
Natural Product Letters
Abstract
Abstract (4R)-Musclide-A2 and (2R,5R)- and (2S,5R)-musclide-B were synthesized from L-leucine and their enantiomers from D-leucine. Comparisons of spectral and [α]D data of synthetic and natural musclides indicated that the absolute configuration at C-4 of natural musclide-A2 and that at C-5 of natural musclide-B should be 4S. Thus, the structures of natural musclides-A2 and -B are revised to (4S)-1 -hydroxy-6-methylhept-4-yl hydrogen sulfate and (2R,5S)-2-hydroxy-7-methyloct-5-yl hydrogen sulfate, respectively.