A. F. Shalas, Siswandono, Marcellino Rudyanto
Apr 20, 2016
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Journal
International Journal of Pharmacy and Pharmaceutical Sciences
Abstract
Objective: The research was aimed to synthesize 1-allyl-3-(2-chlorobenzoyl) thiourea and determine its analgesic activity in mice ( Mus musculus ). Methods: The synthesis was carried out by modified Schotten-Baumann reaction, via nucleophilic substitution reaction of allylthiourea on 2-chlorobenzoyl chloride. The analgesic test was done by writhing test on mice ( Mus musculus ). Results: Pure 1-allyl-3-(2-chlorobenzoyl) thiourea was obtained, confirmed by means of UV, IR, 1 H-NMR, 13 C-NMR, and MS spectroscopy. The compound showed better pain inhibition activity compared to diclofenac sodium, with ED 50 = 15.440 mg/kg BW. Conclusion: The compound 1-allyl-3-(2-chlorobenzoyl) thiourea can be synthesized by one-step modified Schotten-Baumann reaction, and showed a good analgesic activity. The compound needs further investigation as a potential analgesic drug candidate. Keywords: 1-allyl-3-(2-chlorobenzoyl)thiourea, Modified Schotten-Baumann , Analgesic activity