G. Ho, A. Bercovici, D. Tulshian
Jun 1, 2007
Citations
0
Influential Citations
17
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
A series of 4-[2-(aminomethyl)phenyl]-1-[bis(2-chlorophenyl)methyl]-4-hydroxypiperidine analogs has been identified as nociceptin receptor ligands. These compounds display high affinity and functional activity at the nociceptin receptor. The synthesis and structure-activity relationships at the C-4 phenyl and N-1 positions are described and the antitussive activity of a selected compound is reported.