S. Nanduri, Vijay Kumar Nyavanandi, Siva Sanjeeva Rao Thunuguntla
Sep 20, 2004
Citations
4
Influential Citations
183
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
Andrographolide 1, the cytotoxic agent of the plant Andrographis paniculata was subjected to semi-synthetic studies leading to the preparation of a number of potent and novel analogues. Of the analogues synthesized, while 8,17-epoxy andrographolide 6 retained the cytotoxic activity of 1, ester derivatives of 6 exhibited considerable improvement in activity. Lower activity was observed when the epoxy moiety in the triacetate 9, derived from 6 was modified. Synthesis and structure-activity relationships are discussed.