Y. Ozoe, Toyoji. Takayama, Yoshihiro. Sawada
Nov 1, 1993
Citations
0
Influential Citations
14
Citations
Journal
Journal of Agricultural and Food Chemistry
Abstract
Chlorinated analogues of 5-substituted 2,3:8,7-endo-4,6-dioxatricyclo[7.2.1.0 2,8 ]dodec-10-ene (DTD) and 2,3:8,7-endo-4,6-dioxa-5-thiatricyclo[7.1.1.0 2,8 ]dodec-10-ene 5-oxide were prepared. With -CH 2 -, -CH(Me)-, and -S(O)- at the 5 position, the presence of chlorine atoms in the norbornene moiety was important in exerting toxic effects to houseflies, while with -CH(n-Pr)- and -CH(Ph-CN-4)- the introduction of chlorine atoms resulted in a loss of toxic activity. The effect of the presence of chlorine atoms on the potency in inhibiting [ 35 S]tert-butylbicyclophosphorothionate (TBPS) binding to rat brain membranes was found to be correlated to their insecticidal activite