Nan Zhang, Biqi Wu, D. Powell
Dec 18, 2000
Citations
1
Influential Citations
42
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
A series of 3-cyano-4-(phenoxyanilino)cyanoquinolines has been prepared as MEK (MAP kinase kinase) inhibitors. The best activity is seen with alkoxy groups at both the 6- and 7-positions. The lead compounds show low nanomolar IC50's against MAP kinase kinase, and have potent inhibitory activity in tumor cells.