Xie Jun
2006
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Journal
Journal of Guiyang Medical College
Abstract
Objective: To synthesize 2-benzyloxy-5-fluoro-4-oxo-pyrimidine-3-butyric acid ethyl ester,the key intermediate in the synthesis of fluorouracil derivatives.Methods: 2-benzyloxy-5-fluoro-4-oxo-pyrimidine-3-butyric acid ethyl ester was synthesized by using 5-fluorouracil as the starting material through four steps.Its structure was identified with IR and 1H-NMR.Results: Two compounds were obtained in the last step.Conclusions:One compound is identified as the title compound 2-benzyloxy-5-fluoro-4-oxo-pyrimidine-3-butyric acid ethyl ester,and the other one is its formula isomer.