R. Kumar, Y. Joshi
Jun 20, 2007
Citations
1
Influential Citations
47
Citations
Journal
Arkivoc
Abstract
Chlorination of 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo [4,3-d] pyrimidin-7-one (1) with POCl3, afforded 5-(2-ethoxyphenyl)-1-methyl-7-chloro-1H-pyrazolo [4,3-d] pyrimidine (2). Further, compound 2 condensed with different β-diketones/ β-ketoesters 3a-e, to obtain new β-diketones/ β-ketoesters 4a-e. These β-diketones/ β-ketoesters 4a-e were condensed with o-phenylenediamine (o-PDA) to give biologically active 3H-1, 5benzodiazepines 5a-e. KeywordsPyrazolo [4,3-d] pyrimidin-7-one, β-diketones/ β-ketoesters, p-toluenesulfonic acid, o-phenylenediamine, 1,5-benzodiazepines, antimicrobial and anthelmintic activities