M. Mangalam, C. S. A. Selvan, C. Sankar
Feb 5, 2017
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Influential Citations
8
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Journal
Journal of Molecular Structure
Abstract
Abstract A new series of N′ -(2 r ,4 c -diaryl-3-azabicyclo[3.3.1]nonan-9-ylidene)pyrazine-2-carbohydrazides ( 8–14 ) were synthesized by the corresponding 2 r ,4 c -diaryl-3-azabicyclo[3.3.1]nonan-9-ones ( 1–7 ) reaction with pyrazine-2-carbohydrazide. The stereochemistry of the newly synthesized compounds were unambiguously assigned using FT-IR, 1 H, 13 C, and 2D (COSY, HSQC, HMBC, ROESY) nuclear magnetic resonance (NMR) spectral data. The chemical shifts suggest that all these compounds adopt twin-chair conformation with equatorial orientation of aryl substitutions in solution. Hydrazones were screened for their in vitro antitubercular activity against Mycobacterium tuberculosis H 37 Rv and antibacterial activity against a set of pathogenic bacteria. Most of the halogenated compounds showed promising antitubercular and antibacterial activities.