Shenlin Huang, Ronghua Li, P. Connolly
Apr 15, 2007
Citations
0
Influential Citations
13
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
The series of 2-amino-4-aryl-5-chloropyrimidines was discovered to be potent for both VEGFR-2 and CDK1. Described here are the chemistry for analogue synthesis, SAR study, and its kinase selectivity prolifing. The full rat PK data and in vivo efficacy study are also included.