A. A. Lebedev, I. A. Markushina, G. E. Marinicheva
Apr 1, 1981
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Journal
Pharmaceutical Chemistry Journal
Abstract
2-Arylamino-6-methylnicotinic Acid Alkylamides (V-XIII). A solution of 0.01 mole of the 2-chloro-6-methylnicotinic acid alkylamide and 0.01 mole of the arylamine in 20 ml of 50% acetic acid was boiled for 6 h, cooled, and neutralized with a 10% solution of sodium hydroxide. The precipitate which separated was filtered off and recrystallized from a mixture of benzene and hexane (1:2). The hydrochlorides of V-XIII were obtained by passing dry hydroge n chloride through a solution of the base in anhydrous ether.