V. Chumakov, A. Demchenko, A. N. Krasovskii
Aug 1, 1999
Citations
0
Influential Citations
2
Citations
Journal
Pharmaceutical Chemistry Journal
Abstract
As is known, the class of imidazo[2,1-b]thiazole derivatives contains compounds possessing analgesic [1] and antiinflammatory [24] activity. In continuation of previous investigations [5, 6], we have synthesized a series of 2phenylimino-3-phenacyl-4-methylthiazoline hydrobromides ( I Ia l id ) using reactions of 2-phenylamino-4-methylthiazole (I) with aromatic o~-halogenoketones. Upon boiling these salts in a 48% aqueous hydrobromic acid solution, we have isolated 3-methyl-6-(p-tolyl)-7-phenylimidazo[2, l-b] thiazolium bromide (Ill). At the same time, boiling salts Ila lid in acetic anhydride leads to 3,6-dimethyl-5-(p-R-benzoyl)-7phenylimidazo[2,1-b]thiazolium bromides OVa IVd).