M. Pavlova, A. Mikhalev, M. E. Kon’shin
Dec 1, 2001
Citations
0
Influential Citations
4
Citations
Journal
Pharmaceutical Chemistry Journal
Abstract
Previously, we have synthesized alkyl(aryl)amides of 2-chloro-, 2-amino-, and 2-arylaminonicotinic acids possessing anticonvulsant activity [1, 2]; 2-chloro-, 2-methoxy-, and 2-hydroxynicitinic acid amides, some of which exhibited antiinflammatory activity [3, 4]; and 2-arylhydroxynicotinonitriles and unsubstituted amides of 2-arylhydroxynicotinic acids producing antiinflammatory and hypoglycemic effects [5]. In the search for new antiinflammatory and antibacterial agents in the group of 2-substituted nicotinic acid amides, we have synthesized a series of nicotinamides containing pharmacophore 4-sulfamylanilino or aryloxy groups at C-2 atom of the pyridine ring.