N. Cabezas, M. Martínez, E. Gálvez
Feb 1, 1988
Citations
0
Influential Citations
6
Citations
Journal
Journal of Molecular Structure
Abstract
Abstract N -(8-Isopropyl-nortropan-3-α-yl)-2-methoxy-4-amino-5-chlorobenzamide has been synthesized and its crystal and molecular structures determined by X-ray diffraction, IR, 1 H-NMR and 13 C-NMR methods. The pyrrolidine and piperidine rings adopt a flattened N-8 envelope and distorted chair conformation puckered at N-8 and flattened at C-3 respectively, with the N -isopropyl substituent and the amido group in axial position with respect to the piperidine ring. A great predominance in solution of the conformer observed in the solid state is proposed.