Holboyev Yusufjon Khakimovich, Abdurakhmanov Ulugbek Kurganbaevich, Makhsumov Abdukhamid Gafurovich
Oct 20, 2022
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Journal
Journal of Pharmaceutical Negative Results
Abstract
The proposed article relates to organic chemical synthesis and the study of bis-azourea compounds, the chemical properties of new N,N1 derivatives - hexamethylene bis-[(4,41-dimethyldiphenyl)-azo-2,21-diamino) ureas]. The interaction of [(4,41-dimethyldiphenyl)-azo-2,21-diamino)-urea] with hexamethylene diisocyanate gave derivatives N,N1 - hexamethylene bis-[(4,41-dimethyldiphenyl)-azo-2,21-diamino) ureas]. The structure of N,N1 - hexamethylene bis-[(4,41-dimethyldiphenyl)-azo-2,21-diamino)urea] was established by elemental analysis, IR and PMR spectroscopy. Reactivity of NH reaction centers N,N1 - hexamethylene bis-[(4,41-dimethyldiphenyl)-azo-2,21-diamino) urea] is studied by the reactions: N,N1-dinitrosation, N,N1-dimetallation, N,N1 -dialkylation, N,N1-dichlorination. Comparative tests show that the tested derivative of the N,N1 compound - hexamethylene bis-[(4,41-dimethyldiphenyl)-azo-2,21-diamino)urea] showed a higher growth-promoting activity.