M. Aziz
2010
Citations
0
Influential Citations
2
Citations
Journal
Ibn Al-Haitham Journal For Pure And Applied Science
Abstract
L-Phenylalanine amino acid was condensed with 2-hydroxybezaldehyde to give the Schiff base sodium 2-(2-hydroxybenzylideneamino)-3-phenylpropanoate, which was used as a precursor [NaHL]. The precursor was reacted with 1,2-dichloroethane to give the Schiff base sodium 2,2'-(2,2'-(ethane-1,2diylbis(oxy))bis(2,1-phenylene))bis(methan-1-yl-1-ylidene)bis(azan1-yl-1-ylidene)bis(3-phenyl propanoate), which was used as a ligand [Na2L], in complexation with some metal (II) chloride MCl2, where [M= Co(II), Ni(II), Cu(II) and Zn(II)], to give [M(L)] complexes. The [Na2L] ligand and All complexes were characterized by spectroscopic methods, [FTIR, UV-Vis, atomic absorption], melting point, chloride content, conductivity and magnetic susceptibility measurements, as well as the Na2L ligand characterized by 1 H NMR. The data, of these studies and measurements were important to suggest an octahedral geometry around Co(II), Ni(II), Cu(II) and Zn(II) ions. The synthesized ligand, along with its metal complexes, was screened for in vitro antibacterial activity against gram-positive bacteria like Staphylococcus aureus, and Acinetobacter baumannii. This study showed an effective inhibition of grampositive bacteria. Introduction Schiff bases have been used as chelating ligands in the field of coordination chemistry and their metal complexes are of great interest for many years [1]. Chemists have reported on the chemical, structural and biological properties of Schiff bases, Schiff bases are characterized by the -N=CH(imine) group which is important in elucidating the mechanism of transamination and rasemination reaction in biological system [2, 3]. Schiff base metal complexes have been widely studied because they have industrial, antifungal, antibacterial, anticancer and herbicidal applications [4, 5]. They serve as models for b iologically important species and find applications in bio mimetic catalytic reactions, Schiff bases are active against a wide range of organisms, for example; Candida Albicans, Escherichia coli Staphylococcus aureus, Bacillus polymxa, the Trychophyton gypseum. Antibacterial activity has been studied more than antifungal activity , because bacterium can achieve resistance to antibiotics through biochemical and morphological modifications [6, 7]. Chelating ligands containing N, S and O donor atoms showed a broad biological activity and are of special interest because of the variety of ways in which they are bonded to metal ions. It is known that the existence of metal ions bonded to biologically active compounds may enhance their activities [8-10]. The aim of the present study is to synthesis, IHJPAS