N. Cabezas, M. Martínez, E. Gálvez
Jun 1, 1989
Citations
0
Influential Citations
6
Citations
Journal
Journal of Molecular Structure
Abstract
Abstract N -(8-Isopropyl-nortropan-3-β-yl)-2-methoxy-4-amino-5-chlorobenzamide has been synthesized and its crystal and molecular structures determined by X-ray diffraction, IR, 1 H NMR and 13 C NMR methods. The pyrrolidine and piperidine rings adopt a flattened N-8 envelope and distorted chair conformation puckered at N-8, with the N -isopropyl substituent and the amido groups, respectively, in axial and equatorial position with respect to the piperidine ring. A great predominance in solution of the conformer observed in the solid state is proposed. The results obtained are compared with those previously found for the corresponding α-epimer.